Could you tell me what software was used by Michelle Phan to create this story of her life?
There are many possible combinations to achieve that result. I'll guess any drawing/illustrating software (Photoshop, Paint.net, GIMP, Paintool SAI, Illustrator, etc,etc) and a screencasting software (Camtasia, Microsoft Expression Encoder's screencasting tool, etc)
Oh, I was about to suggest contacting her directly, but Hovsep already provides the link. She explained under the video.
photoshop and wacom tablet to draw