Online calculator with a twist. xThink calculator lets you write and solve problems using your mouse instead of a keyboard. You’re provided with a dashboard where you can only use the mouse cursor (or external drawing pad) to sketch a problem, for example if you scribble 34×57 and click “Solve”, xThink will calculate it and show you the solution.

Pretty handy website for those who got a drawing pad. As for everyone else there are eCalc, InstaCalc and Calc5.
xthink Features:
Check out xThink Calc @ www.xthink.net/calc/
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Seems to be a nice tool technically, really appriciate the work .. but if you compare in terms of usability I still find old desktop calculator better.